Parkinson's disease: genetics and pathogenesis
JM Shulman, PL De Jager… - Annual Review of …, 2011 - annualreviews.org
Recent investigation into the mechanisms of Parkinson's disease (PD) has generated remarkable
insight while simultaneously challenging traditional conceptual frameworks. Although …
insight while simultaneously challenging traditional conceptual frameworks. Although …
Genetics and pathogenesis of Parkinson's syndrome
…, M Yu, M Cykowski, JM Shulman - Annual Review of …, 2023 - annualreviews.org
… The authors also thank Huda Zoghbi, Chad Shaw, John Hardy, Niccolo Mencacci, and Lisa
Shulman for helpful discussions and comments on the manuscript. HY is supported by the …
Shulman for helpful discussions and comments on the manuscript. HY is supported by the …
A mitocentric view of Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disease, yet the underlying
causative molecular mechanisms are ill defined. Numerous observations based on drug studies …
causative molecular mechanisms are ill defined. Numerous observations based on drug studies …
A typology of social entrepreneurs: Motives, search processes and ethical challenges
Social entrepreneurship has been the subject of considerable interest in the literature. This
stems from its importance in addressing social problems and enriching communities and …
stems from its importance in addressing social problems and enriching communities and …
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …
the scope of biological knowledge about the disease over the past decade. We aimed to …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles
CW Wittmann, MF Wszolek, JM Shulman… - Science, 2001 - science.org
The microtubule-binding protein tau has been implicated in the pathogenesis of Alzheimer's
disease and related disorders. However, the mechanisms underlying tau-mediated …
disease and related disorders. However, the mechanisms underlying tau-mediated …
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
JD Axelrod, JR Miller, JM Shulman… - Genes & …, 1998 - genesdev.cshlp.org
In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz)
and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may …
and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may …
[HTML][HTML] Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
Planar cell polarity signaling in Drosophila requires the receptor Frizzled and the cytoplasmic
proteins Dishevelled and Prickle. From initial, symmetric subcellular distributions in pupal …
proteins Dishevelled and Prickle. From initial, symmetric subcellular distributions in pupal …
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
…, KES Matlack, CY Chung, V Baru, JM Shulman… - Science, 2011 - science.org
Aβ (beta-amyloid peptide) is an important contributor to Alzheimer’s disease (AD). We
modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide …
modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide …