The addition of leucovorin (LV) to 5-fluorouracil (5-FU) in advanced colorectal cancer has
shown improved tumour response rates in many trials, but the optimal LV/5-FU regimen has …

… Krulik was responsible for the undergraduate and graduate preparation of mathematics
teachers for grades K–12, as well as the in-service alertness training of mathematics teachers at …

CPT-11 (irinotecan) has shown activity in patients with advanced colorectal cancer resistant
to leucovorin (LV) and 5-fluorouracil (5-FU). In this study, the simplified bimonthly LV–5-FU …

We develop a systematic algorithm to construct, classify and study exact solutions of type IIA/B
supergravity which are time-dependent and homogeneous and, hence, represent …

… Krulik was responsible for the undergraduate and graduate preparation of mathematics teachers
for grades K-… Krulik received his BA degree in mathematics from Brooklyn College of the …

Oxaliplatin has shown in vivo cytotoxic activity against colorectal cell lines. Preliminary studies
suggest potentiation of fluorouracil (5-FU). To assess this issue, we performed a phase II …

This book combines suggestions for the teaching of problem solving with activities and
carefully discussed non-routine problems which students should find interesting as they gain …

Many teachers and administrators have recognized that problem solving and reasoning
represent two of the primary goals in the education of children. In order for teachers to achieve …

The teaching of problem solving begins the moment a child first enters school and the senior
high school plays a major role in the development of this skill since a number of students …

During the past decade, problem solving has become a major focus of the mathematics
curriculum. Many feel that in this era of increasing technology, it is important for students to learn …