Combination therapies exploit the chances for better efficacy, decreased toxicity, and reduced
development of drug resistance and owing to these advantages, have become a standard …

The 2014–2015 outbreak of Ebola virus disease is the largest epidemic to date in terms of
the number of cases, deaths, and affected areas. In October 2015, no antiviral agents had …

Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late
clinical presentation and the lack of effective non-surgical therapies. Unfortunately, most of the …

Let X be a projective manifold and f: X → X a rational mapping with large topological degree,
$d_{t}>\lambda _{k-1}(f)$:= the $(k-1)^{\text{th}}$ dynamical degree of f. We give an …

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular
entities focused on ‘small’ chemical compounds. The molecular entities in question are either …

During the last 3 years, a number of approaches for the normalization of RNA sequencing
data have emerged in the literature, differing both in the type of bias adjustment and in the …

Background The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial.
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …

Purpose In the context of the worldwide outbreak of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), some patients report functional complaints after apparent recovery …

Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral
drug or vaccine is yet available for the treatment of this disease 1 , 2 – 3 . Several clinical …

A time series analysis of 871 543 pediatric emergency visits revealed that the coronavirus
disease 2019 (COVID-19) lockdown and school closures were associated with a significant …