… As human cancers develop in an immunocompetent host, tumour development is shaped
by the host’s immune system via a process called cancer immunoediting, and eventually …

Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand
1 (PD-L1) pathway can induce robust and durable responses in patients with various …

The immunoglobulin heavy-chain (IgH) locus undergoes large-scale contraction in B cells
poised to undergo IgH V(D)J recombination. We considered the possibility that looping of …

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre-…

… Rather than a common set of J gene segments located upstream of the constant region(s),
the four constant regions of Igλ each contain their own unique Jλ gene segment. Moreover, …

… A purely computational approach, including a MHCI-haplotype-specific structural prediction,
would require only whole-exome/transcriptome sequencing of a patient’s tumour, which is …

We describe results from IMmotion150, a randomized phase 2 study of atezolizumab (anti-PD-L1)
alone or combined with bevacizumab (anti-VEGF) versus sunitinib in 305 patients with …

The efficacy of implanted biomedical devices is often compromised by host recognition and
subsequent foreign body responses. Here, we demonstrate the role of the geometry of …

… 78430, Thermo Scientific) on ice and then lysed by sonication (for 30 s on, 30 s off; twice
at 70% amplitude). Samples were then subjected to constant agitation for 2 h at 4 C. Lysates …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …